2011年8月2日 星期二

Why Cancer and Inflammation?

Seth Rakoff-Nahoum

Abstract

Central to the development of cancer are genetic changes that endow these “cancer cells” with many of the hallmarks of cancer, such as self-sufficient growth and resistance to antigrowth and pro-death signals. However, while the genetic changes that occur within cancer cells  themselves, such as activated oncogenes or dysfunctional tumor suppressors, are responsible for many aspects of cancer development, they are not sufficient. Tumor promotion and  progression are dependent on ancillary processes provided by cells of the tumor environment
but that are not necessarily cancerous themselves. Inflammation has long been associated with the development of cancer. This review will discuss the reflexive relationship between cancer and inflammation with particular focus on how considering the role of inflammation in physiologic processes such as the maintenance of tissue homeostasis and repair may provide a logical framework for understanding the connection between the inflammatory response and cancer.

中文摘要:
癌症之發生主要源自於基因之改變,這些改變是癌症細胞擁有好幾個特徵,即自主生長,能抗拒抑制生長和摧毀凋零之訊息。雖然,引起癌化之基因改變是發生在細胞裡面;諸如癌化基因之啟動或抑制癌化基因之因子失去功能,這些都能引起癌症,但是只有這些是不夠的。腫瘤之進展需要一些由周邊正常細胞所提供之輔助環境條件。發炎很早便被認定與癌症發展有關。本論文會討論癌症和發炎的反射反應關係,特別從發炎之生理過程及其維持生理系統平衡和修補來了解發炎及癌症之因果關係。


檔案下載

沒有留言:

張貼留言