2011年8月9日 星期二

NFkB/p53 crosstalk - a promising new therapeutic target

Gunter Schneider, Oliver H. Kramer

Abstract

The transcription factors p53 and NFkB determine cellular fate and are involved in the pathogenesis of most-if not all-cancers. The crosstalk between these transcription factors becomes increasingly appreciated as an important mechanism operative during all stages of tumorigenesis, metastasis, and immunological surveillance. In this review, we summarize molecular mechanisms resulating cross-signaling between p53 and NFkB proteins and how dysregulated interactions between p53 and NFkB family members contribute to oncogenesis. We furthermore analyze how such signaling modules represent targets for the design of novel intervention strategies using established compounds and powerful combination therapies.


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